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KMID : 0377619880530090613
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Korean Jungang Medical Journal
1988 Volume.53 No. 9 p.613 ~ p.618
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Immunohistochemical Study on Myxoid Malignant Fibrous Histiocytoma Histogenesis
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Abstract
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The malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma in adult life. The cellular origin of MFH claimed that the tumor originates from tissue histiocyte which may undergo transformation to a facultative fibroblast. Others suggest that a primitive mesenchymal cell gives rise to two cell lines, one revealing histiocytic and the other showing fibroblastic differentiation. This MFH shows a broad range of histological appearance, so it is divided into the several subtypes: storiform-pleomorphic, myxoid, giant cell, inflammatory and angiomatoid. The myxoid form of MFH is characterized by myxoid areas in association with cellular areas indistinguishable from typical MFH.
This is a case report of myxoid malignant fibrous histiocytoma, arising in the right lower extremity of 66 year old male patient. The patient was taken first operation "below knee amputation" under impression of MFH (1988. March), but recurrence was developed about 2 months after (1988. May). He was taken above knee amputation. The specimens were myxoid, lobulated and bulky neoplastic tissue overlying skin, measuring 15xl0x9 cm and weighting 850 gm. Cut surface show typical fish flesh appearance and multifocal hemorrhagic necrosis.
The prominent microscopic findings show extensive myxoid areas revealing widely spaced spindled & pleomorphic cells in a matrix of acid mucopolysacchaide.
The immunohistochemical staining for ai -antitrypsin, ai -antichymotrypsin, lysozyme and C3 receptor were negative, but vimentin was positive.
These results were hightly suggested that the cellular origin of the myxoid MFH is not a histiocyte.
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KEYWORD
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